diff --git a/telegram/ext/filters.py b/telegram/ext/filters.py
index a8fef2e0a..0e15cd0cb 100644
--- a/telegram/ext/filters.py
+++ b/telegram/ext/filters.py
@@ -66,6 +66,7 @@ __all__ = (
     "LOCATION",
     "Language",
     "MessageFilter",
+    "Mention",
     "PASSPORT_DATA",
     "PHOTO",
     "POLL",
@@ -91,7 +92,6 @@ __all__ = (
     "VOICE",
     "ViaBot",
 )
-
 import mimetypes
 import re
 from abc import ABC, abstractmethod
@@ -99,6 +99,7 @@ from typing import (
     Collection,
     Dict,
     FrozenSet,
+    Iterable,
     List,
     Match,
     NoReturn,
@@ -1521,6 +1522,73 @@ LOCATION = _Location(name="filters.LOCATION")
 """Messages that contain :attr:`telegram.Message.location`."""
 
 
+class Mention(MessageFilter):
+    """Messages containing mentions of specified users or chats.
+
+    Examples:
+        .. code-block:: python
+
+            MessageHandler(filters.Mention("username"), callback)
+            MessageHandler(filters.Mention(["@username", 123456]), callback)
+
+    .. versionadded:: NEXT.VERSION
+
+    Args:
+        mentions (:obj:`int` | :obj:`str` | :class:`telegram.User` | Collection[:obj:`int` | \
+            :obj:`str` | :class:`telegram.User`]):
+            Specifies the users and chats to filter for. Messages that do not mention at least one
+            of the specified users or chats will not be handled. Leading ``'@'`` s in usernames
+            will be discarded.
+    """
+
+    __slots__ = ("_mentions",)
+
+    def __init__(self, mentions: SCT[Union[int, str, TGUser]]):
+        super().__init__(name=f"filters.Mention({mentions})")
+        if isinstance(mentions, Iterable) and not isinstance(mentions, str):
+            self._mentions = {self._fix_mention_username(mention) for mention in mentions}
+        else:
+            self._mentions = {self._fix_mention_username(mentions)}
+
+    @staticmethod
+    def _fix_mention_username(mention: Union[int, str, TGUser]) -> Union[int, str, TGUser]:
+        if not isinstance(mention, str):
+            return mention
+        return mention.lstrip("@")
+
+    @classmethod
+    def _check_mention(cls, message: Message, mention: Union[int, str, TGUser]) -> bool:
+        if not message.entities:
+            return False
+
+        entity_texts = message.parse_entities(
+            types=[MessageEntity.MENTION, MessageEntity.TEXT_MENTION]
+        )
+
+        if isinstance(mention, TGUser):
+            return any(
+                mention.id == entity.user.id
+                or mention.username == entity.user.username
+                or mention.username == cls._fix_mention_username(entity_texts[entity])
+                for entity in message.entities
+                if entity.user
+            ) or any(
+                mention.username == cls._fix_mention_username(entity_text)
+                for entity_text in entity_texts.values()
+            )
+        if isinstance(mention, int):
+            return bool(
+                any(mention == entity.user.id for entity in message.entities if entity.user)
+            )
+        return any(
+            mention == cls._fix_mention_username(entity_text)
+            for entity_text in entity_texts.values()
+        )
+
+    def filter(self, message: Message) -> bool:
+        return any(self._check_mention(message, mention) for mention in self._mentions)
+
+
 class _PassportData(MessageFilter):
     __slots__ = ()
 
diff --git a/tests/ext/test_filters.py b/tests/ext/test_filters.py
index 760c41c56..f0812db66 100644
--- a/tests/ext/test_filters.py
+++ b/tests/ext/test_filters.py
@@ -2423,3 +2423,65 @@ class TestFilters:
             ),
         )
         assert filters.ATTACHMENT.check_update(up)
+
+    def test_filters_mention_no_entities(self, update):
+        update.message.text = "test"
+        assert not filters.Mention("@test").check_update(update)
+        assert not filters.Mention(123456).check_update(update)
+        assert not filters.Mention("123456").check_update(update)
+        assert not filters.Mention(User(1, "first_name", False)).check_update(update)
+        assert not filters.Mention(
+            ["@test", 123456, "123456", User(1, "first_name", False)]
+        ).check_update(update)
+
+    def test_filters_mention_type_mention(self, update):
+        update.message.text = "@test1 @test2 user"
+        update.message.entities = [
+            MessageEntity(MessageEntity.MENTION, 0, 6),
+            MessageEntity(MessageEntity.MENTION, 7, 6),
+        ]
+
+        user_no_username = User(123456, "first_name", False)
+        user_wrong_username = User(123456, "first_name", False, username="wrong")
+        user_1 = User(111, "first_name", False, username="test1")
+        user_2 = User(222, "first_name", False, username="test2")
+
+        for username in ("@test1", "@test2"):
+            assert filters.Mention(username).check_update(update)
+            assert filters.Mention({username}).check_update(update)
+
+        for user in (user_1, user_2):
+            assert filters.Mention(user).check_update(update)
+            assert filters.Mention({user}).check_update(update)
+
+        assert not filters.Mention(
+            ["@test3", 123, user_no_username, user_wrong_username]
+        ).check_update(update)
+
+    def test_filters_mention_type_text_mention(self, update):
+        user_1 = User(111, "first_name", False, username="test1")
+        user_2 = User(222, "first_name", False, username="test2")
+        user_no_username = User(123456, "first_name", False)
+        user_wrong_username = User(123456, "first_name", False, username="wrong")
+
+        update.message.text = "test1 test2 user"
+        update.message.entities = [
+            MessageEntity(MessageEntity.TEXT_MENTION, 0, 5, user=user_1),
+            MessageEntity(MessageEntity.TEXT_MENTION, 6, 5, user=user_2),
+        ]
+
+        for username in ("@test1", "@test2"):
+            assert filters.Mention(username).check_update(update)
+            assert filters.Mention({username}).check_update(update)
+
+        for user in (user_1, user_2):
+            assert filters.Mention(user).check_update(update)
+            assert filters.Mention({user}).check_update(update)
+
+        for user_id in (111, 222):
+            assert filters.Mention(user_id).check_update(update)
+            assert filters.Mention({user_id}).check_update(update)
+
+        assert not filters.Mention(
+            ["@test3", 123, user_no_username, user_wrong_username]
+        ).check_update(update)