diff --git a/.github/workflows/type_completeness_monthly.yml b/.github/workflows/type_completeness_monthly.yml
new file mode 100644
index 000000000..a5492f903
--- /dev/null
+++ b/.github/workflows/type_completeness_monthly.yml
@@ -0,0 +1,33 @@
+name: Check Type Completeness Monthly Run
+on:
+  schedule:
+    # Run first friday of the month at 03:17 - odd time to spread load on GitHub Actions
+    - cron: '17 3 1-7 * 5'
+
+jobs:
+  test-type-completeness:
+    name:   test-type-completeness
+    runs-on: ubuntu-latest
+    steps:
+      - uses: Bibo-Joshi/pyright-type-completeness@1.0.0
+        id: pyright-type-completeness
+        with:
+          package-name: telegram
+          python-version: 3.12
+          pyright-version: ~=1.1.367
+      - name: Check Output
+        uses: jannekem/run-python-script-action@v1
+        env:
+          TYPE_COMPLETENESS: ${{ steps.pyright-type-completeness.outputs.base-completeness-score }}
+        with:
+          script: |
+            import os
+            completeness = float(os.getenv("TYPE_COMPLETENESS"))
+            
+            if completeness >= 1:
+                exit(0)
+            
+            text = f"Type Completeness Decreased to {completeness}. ❌"
+            error(text)
+            set_summary(text)
+            exit(1)
diff --git a/examples/nestedconversationbot.py b/examples/nestedconversationbot.py
index 918f0becf..fdc49de2b 100644
--- a/examples/nestedconversationbot.py
+++ b/examples/nestedconversationbot.py
@@ -371,8 +371,8 @@ def main() -> None:
         entry_points=[CommandHandler("start", start)],
         states={
             SHOWING: [CallbackQueryHandler(start, pattern="^" + str(END) + "$")],
-            SELECTING_ACTION: selection_handlers,
-            SELECTING_LEVEL: selection_handlers,
+            SELECTING_ACTION: selection_handlers,  # type: ignore[dict-item]
+            SELECTING_LEVEL: selection_handlers,  # type: ignore[dict-item]
             DESCRIBING_SELF: [description_conv],
             STOPPING: [CommandHandler("start", start)],
         },
diff --git a/telegram/ext/_application.py b/telegram/ext/_application.py
index a1013ce57..86e38b1de 100644
--- a/telegram/ext/_application.py
+++ b/telegram/ext/_application.py
@@ -323,7 +323,7 @@ class Application(Generic[BT, CCT, UD, CD, BD, JQ], AsyncContextManager["Applica
         self.update_queue: asyncio.Queue[object] = update_queue
         self.context_types: ContextTypes[CCT, UD, CD, BD] = context_types
         self.updater: Optional[Updater] = updater
-        self.handlers: Dict[int, List[BaseHandler[Any, CCT]]] = {}
+        self.handlers: Dict[int, List[BaseHandler[Any, CCT, Any]]] = {}
         self.error_handlers: Dict[
             HandlerCallback[object, CCT, None], Union[bool, DefaultValue[bool]]
         ] = {}
@@ -1352,7 +1352,7 @@ class Application(Generic[BT, CCT, UD, CD, BD, JQ], AsyncContextManager["Applica
             # (in __create_task_callback)
             self._mark_for_persistence_update(update=update)
 
-    def add_handler(self, handler: BaseHandler[Any, CCT], group: int = DEFAULT_GROUP) -> None:
+    def add_handler(self, handler: BaseHandler[Any, CCT, Any], group: int = DEFAULT_GROUP) -> None:
         """Register a handler.
 
         TL;DR: Order and priority counts. 0 or 1 handlers per group will be used. End handling of
@@ -1420,8 +1420,8 @@ class Application(Generic[BT, CCT, UD, CD, BD, JQ], AsyncContextManager["Applica
     def add_handlers(
         self,
         handlers: Union[
-            Union[List[BaseHandler[Any, CCT]], Tuple[BaseHandler[Any, CCT]]],
-            Dict[int, Union[List[BaseHandler[Any, CCT]], Tuple[BaseHandler[Any, CCT]]]],
+            Union[List[BaseHandler[Any, CCT, Any]], Tuple[BaseHandler[Any, CCT, Any]]],
+            Dict[int, Union[List[BaseHandler[Any, CCT, Any]], Tuple[BaseHandler[Any, CCT, Any]]]],
         ],
         group: Union[int, DefaultValue[int]] = _DEFAULT_0,
     ) -> None:
@@ -1469,7 +1469,9 @@ class Application(Generic[BT, CCT, UD, CD, BD, JQ], AsyncContextManager["Applica
                 "dictionary where the keys are groups and values are sequences of handlers."
             )
 
-    def remove_handler(self, handler: BaseHandler[Any, CCT], group: int = DEFAULT_GROUP) -> None:
+    def remove_handler(
+        self, handler: BaseHandler[Any, CCT, Any], group: int = DEFAULT_GROUP
+    ) -> None:
         """Remove a handler from the specified group.
 
         Args:
diff --git a/telegram/ext/_callbackcontext.py b/telegram/ext/_callbackcontext.py
index ea708e0e6..dfd2c3cc8 100644
--- a/telegram/ext/_callbackcontext.py
+++ b/telegram/ext/_callbackcontext.py
@@ -29,6 +29,7 @@ from typing import (
     NoReturn,
     Optional,
     Type,
+    TypeVar,
     Union,
 )
 
@@ -49,6 +50,9 @@ _STORING_DATA_WIKI = (
     "/wiki/Storing-bot%2C-user-and-chat-related-data"
 )
 
+# something like poor mans "typing.Self" for py<3.11
+ST = TypeVar("ST", bound="CallbackContext[Any, Any, Any, Any]")
+
 
 class CallbackContext(Generic[BT, UD, CD, BD]):
     """
@@ -133,24 +137,24 @@ class CallbackContext(Generic[BT, UD, CD, BD]):
     )
 
     def __init__(
-        self: "CCT",
-        application: "Application[BT, CCT, UD, CD, BD, Any]",
+        self: ST,
+        application: "Application[BT, ST, UD, CD, BD, Any]",
         chat_id: Optional[int] = None,
         user_id: Optional[int] = None,
     ):
-        self._application: Application[BT, CCT, UD, CD, BD, Any] = application
+        self._application: Application[BT, ST, UD, CD, BD, Any] = application
         self._chat_id: Optional[int] = chat_id
         self._user_id: Optional[int] = user_id
         self.args: Optional[List[str]] = None
         self.matches: Optional[List[Match[str]]] = None
         self.error: Optional[Exception] = None
-        self.job: Optional[Job[CCT]] = None
+        self.job: Optional[Job[Any]] = None
         self.coroutine: Optional[
             Union[Generator[Optional[Future[object]], None, Any], Awaitable[Any]]
         ] = None
 
     @property
-    def application(self) -> "Application[BT, CCT, UD, CD, BD, Any]":
+    def application(self) -> "Application[BT, ST, UD, CD, BD, Any]":
         """:class:`telegram.ext.Application`: The application associated with this context."""
         return self._application
 
@@ -398,7 +402,7 @@ class CallbackContext(Generic[BT, UD, CD, BD]):
         return self._application.bot
 
     @property
-    def job_queue(self) -> Optional["JobQueue[CCT]"]:
+    def job_queue(self) -> Optional["JobQueue[ST]"]:
         """
         :class:`telegram.ext.JobQueue`: The :class:`JobQueue` used by the
         :class:`telegram.ext.Application`.
diff --git a/telegram/ext/_handlers/basehandler.py b/telegram/ext/_handlers/basehandler.py
index ea0d9b164..bf6f5f155 100644
--- a/telegram/ext/_handlers/basehandler.py
+++ b/telegram/ext/_handlers/basehandler.py
@@ -32,14 +32,14 @@ RT = TypeVar("RT")
 UT = TypeVar("UT")
 
 
-class BaseHandler(Generic[UT, CCT], ABC):
+class BaseHandler(Generic[UT, CCT, RT], ABC):
     """The base class for all update handlers. Create custom handlers by inheriting from it.
 
     Warning:
         When setting :paramref:`block` to :obj:`False`, you cannot rely on adding custom
         attributes to :class:`telegram.ext.CallbackContext`. See its docs for more info.
 
-    This class is a :class:`~typing.Generic` class and accepts two type variables:
+    This class is a :class:`~typing.Generic` class and accepts three type variables:
 
     1. The type of the updates that this handler will handle. Must coincide with the type of the
        first argument of :paramref:`callback`. :meth:`check_update` must only accept
@@ -54,6 +54,7 @@ class BaseHandler(Generic[UT, CCT], ABC):
            For this type variable, one should usually provide a :class:`~typing.TypeVar` that is
            also used for the mentioned method arguments. That way, a type checker can check whether
            this handler fits the definition of the :class:`~Application`.
+    3. The return type of the :paramref:`callback` function accepted by this handler.
 
     .. seealso:: :wiki:`Types of Handlers <Types-of-Handlers>`
 
@@ -89,7 +90,7 @@ class BaseHandler(Generic[UT, CCT], ABC):
     )
 
     def __init__(
-        self,
+        self: "BaseHandler[UT, CCT, RT]",
         callback: HandlerCallback[UT, CCT, RT],
         block: DVType[bool] = DEFAULT_TRUE,
     ):
diff --git a/telegram/ext/_handlers/businessconnectionhandler.py b/telegram/ext/_handlers/businessconnectionhandler.py
index c8cb3e843..e5d09c77c 100644
--- a/telegram/ext/_handlers/businessconnectionhandler.py
+++ b/telegram/ext/_handlers/businessconnectionhandler.py
@@ -29,7 +29,7 @@ from telegram.ext._utils.types import CCT, HandlerCallback
 RT = TypeVar("RT")
 
 
-class BusinessConnectionHandler(BaseHandler[Update, CCT]):
+class BusinessConnectionHandler(BaseHandler[Update, CCT, RT]):
     """Handler class to handle Telegram
     :attr:`Business Connections <telegram.Update.business_connection>`.
 
@@ -65,7 +65,7 @@ class BusinessConnectionHandler(BaseHandler[Update, CCT]):
     )
 
     def __init__(
-        self,
+        self: "BusinessConnectionHandler[CCT, RT]",
         callback: HandlerCallback[Update, CCT, RT],
         user_id: Optional[SCT[int]] = None,
         username: Optional[SCT[str]] = None,
diff --git a/telegram/ext/_handlers/businessmessagesdeletedhandler.py b/telegram/ext/_handlers/businessmessagesdeletedhandler.py
index 0ceb58fe0..c041bb0ad 100644
--- a/telegram/ext/_handlers/businessmessagesdeletedhandler.py
+++ b/telegram/ext/_handlers/businessmessagesdeletedhandler.py
@@ -29,7 +29,7 @@ from telegram.ext._utils.types import CCT, HandlerCallback
 RT = TypeVar("RT")
 
 
-class BusinessMessagesDeletedHandler(BaseHandler[Update, CCT]):
+class BusinessMessagesDeletedHandler(BaseHandler[Update, CCT, RT]):
     """Handler class to handle
     :attr:`deleted Telegram Business messages <telegram.Update.deleted_business_messages>`.
 
@@ -65,7 +65,7 @@ class BusinessMessagesDeletedHandler(BaseHandler[Update, CCT]):
     )
 
     def __init__(
-        self,
+        self: "BusinessMessagesDeletedHandler[CCT, RT]",
         callback: HandlerCallback[Update, CCT, RT],
         chat_id: Optional[SCT[int]] = None,
         username: Optional[SCT[str]] = None,
diff --git a/telegram/ext/_handlers/callbackqueryhandler.py b/telegram/ext/_handlers/callbackqueryhandler.py
index a149739a2..5e0a0a12a 100644
--- a/telegram/ext/_handlers/callbackqueryhandler.py
+++ b/telegram/ext/_handlers/callbackqueryhandler.py
@@ -33,7 +33,7 @@ if TYPE_CHECKING:
 RT = TypeVar("RT")
 
 
-class CallbackQueryHandler(BaseHandler[Update, CCT]):
+class CallbackQueryHandler(BaseHandler[Update, CCT, RT]):
     """Handler class to handle Telegram
     :attr:`callback queries <telegram.Update.callback_query>`. Optionally based on a regex.
 
@@ -125,7 +125,7 @@ class CallbackQueryHandler(BaseHandler[Update, CCT]):
     __slots__ = ("game_pattern", "pattern")
 
     def __init__(
-        self,
+        self: "CallbackQueryHandler[CCT, RT]",
         callback: HandlerCallback[Update, CCT, RT],
         pattern: Optional[
             Union[str, Pattern[str], type, Callable[[object], Optional[bool]]]
diff --git a/telegram/ext/_handlers/chatboosthandler.py b/telegram/ext/_handlers/chatboosthandler.py
index 9d7219632..7a2dd1be6 100644
--- a/telegram/ext/_handlers/chatboosthandler.py
+++ b/telegram/ext/_handlers/chatboosthandler.py
@@ -23,10 +23,10 @@ from typing import Final, Optional
 from telegram import Update
 from telegram.ext._handlers.basehandler import BaseHandler
 from telegram.ext._utils._update_parsing import parse_chat_id, parse_username
-from telegram.ext._utils.types import CCT, HandlerCallback
+from telegram.ext._utils.types import CCT, RT, HandlerCallback
 
 
-class ChatBoostHandler(BaseHandler[Update, CCT]):
+class ChatBoostHandler(BaseHandler[Update, CCT, RT]):
     """
     Handler class to handle Telegram updates that contain a chat boost.
 
@@ -84,8 +84,8 @@ class ChatBoostHandler(BaseHandler[Update, CCT]):
     and :attr:`telegram.Update.removed_chat_boost`."""
 
     def __init__(
-        self,
-        callback: HandlerCallback[Update, CCT, None],
+        self: "ChatBoostHandler[CCT, RT]",
+        callback: HandlerCallback[Update, CCT, RT],
         chat_boost_types: int = CHAT_BOOST,
         chat_id: Optional[int] = None,
         chat_username: Optional[str] = None,
diff --git a/telegram/ext/_handlers/chatjoinrequesthandler.py b/telegram/ext/_handlers/chatjoinrequesthandler.py
index 7007f61ab..04576e63c 100644
--- a/telegram/ext/_handlers/chatjoinrequesthandler.py
+++ b/telegram/ext/_handlers/chatjoinrequesthandler.py
@@ -28,7 +28,7 @@ from telegram.ext._utils._update_parsing import parse_chat_id, parse_username
 from telegram.ext._utils.types import CCT, HandlerCallback
 
 
-class ChatJoinRequestHandler(BaseHandler[Update, CCT]):
+class ChatJoinRequestHandler(BaseHandler[Update, CCT, RT]):
     """Handler class to handle Telegram updates that contain
     :attr:`telegram.Update.chat_join_request`.
 
@@ -81,7 +81,7 @@ class ChatJoinRequestHandler(BaseHandler[Update, CCT]):
     )
 
     def __init__(
-        self,
+        self: "ChatJoinRequestHandler[CCT, RT]",
         callback: HandlerCallback[Update, CCT, RT],
         chat_id: Optional[SCT[int]] = None,
         username: Optional[SCT[str]] = None,
diff --git a/telegram/ext/_handlers/chatmemberhandler.py b/telegram/ext/_handlers/chatmemberhandler.py
index 592361b64..cf8bb28db 100644
--- a/telegram/ext/_handlers/chatmemberhandler.py
+++ b/telegram/ext/_handlers/chatmemberhandler.py
@@ -29,7 +29,7 @@ from telegram.ext._utils.types import CCT, HandlerCallback
 RT = TypeVar("RT")
 
 
-class ChatMemberHandler(BaseHandler[Update, CCT]):
+class ChatMemberHandler(BaseHandler[Update, CCT, RT]):
     """Handler class to handle Telegram updates that contain a chat member update.
 
     Warning:
@@ -87,7 +87,7 @@ class ChatMemberHandler(BaseHandler[Update, CCT]):
     and :attr:`telegram.Update.chat_member`."""
 
     def __init__(
-        self,
+        self: "ChatMemberHandler[CCT, RT]",
         callback: HandlerCallback[Update, CCT, RT],
         chat_member_types: int = MY_CHAT_MEMBER,
         block: DVType[bool] = DEFAULT_TRUE,
diff --git a/telegram/ext/_handlers/choseninlineresulthandler.py b/telegram/ext/_handlers/choseninlineresulthandler.py
index db7a87214..feac28ba6 100644
--- a/telegram/ext/_handlers/choseninlineresulthandler.py
+++ b/telegram/ext/_handlers/choseninlineresulthandler.py
@@ -32,7 +32,7 @@ if TYPE_CHECKING:
     from telegram.ext import Application
 
 
-class ChosenInlineResultHandler(BaseHandler[Update, CCT]):
+class ChosenInlineResultHandler(BaseHandler[Update, CCT, RT]):
     """Handler class to handle Telegram updates that contain
     :attr:`telegram.Update.chosen_inline_result`.
 
@@ -76,7 +76,7 @@ class ChosenInlineResultHandler(BaseHandler[Update, CCT]):
     __slots__ = ("pattern",)
 
     def __init__(
-        self,
+        self: "ChosenInlineResultHandler[CCT, RT]",
         callback: HandlerCallback[Update, CCT, RT],
         block: DVType[bool] = DEFAULT_TRUE,
         pattern: Optional[Union[str, Pattern[str]]] = None,
diff --git a/telegram/ext/_handlers/commandhandler.py b/telegram/ext/_handlers/commandhandler.py
index edad3963a..54d01acd6 100644
--- a/telegram/ext/_handlers/commandhandler.py
+++ b/telegram/ext/_handlers/commandhandler.py
@@ -33,7 +33,7 @@ if TYPE_CHECKING:
 RT = TypeVar("RT")
 
 
-class CommandHandler(BaseHandler[Update, CCT]):
+class CommandHandler(BaseHandler[Update, CCT, RT]):
     """Handler class to handle Telegram commands.
 
     Commands are Telegram messages that start with ``/``, optionally followed by an ``@`` and the
@@ -118,7 +118,7 @@ class CommandHandler(BaseHandler[Update, CCT]):
     __slots__ = ("commands", "filters", "has_args")
 
     def __init__(
-        self,
+        self: "CommandHandler[CCT, RT]",
         command: SCT[str],
         callback: HandlerCallback[Update, CCT, RT],
         filters: Optional[filters_module.BaseFilter] = None,
diff --git a/telegram/ext/_handlers/conversationhandler.py b/telegram/ext/_handlers/conversationhandler.py
index f3fad9f83..83fa373fc 100644
--- a/telegram/ext/_handlers/conversationhandler.py
+++ b/telegram/ext/_handlers/conversationhandler.py
@@ -55,7 +55,7 @@ from telegram.ext._utils.types import CCT, ConversationDict, ConversationKey
 
 if TYPE_CHECKING:
     from telegram.ext import Application, Job, JobQueue
-_CheckUpdateType = Tuple[object, ConversationKey, BaseHandler[Update, CCT], object]
+_CheckUpdateType = Tuple[object, ConversationKey, BaseHandler[Update, CCT, object], object]
 
 _LOGGER = get_logger(__name__, class_name="ConversationHandler")
 
@@ -119,7 +119,7 @@ class PendingState:
         return res
 
 
-class ConversationHandler(BaseHandler[Update, CCT]):
+class ConversationHandler(BaseHandler[Update, CCT, object]):
     """
     A handler to hold a conversation with a single or multiple users through Telegram updates by
     managing three collections of other handlers.
@@ -296,10 +296,10 @@ class ConversationHandler(BaseHandler[Update, CCT]):
 
     # pylint: disable=super-init-not-called
     def __init__(
-        self,
-        entry_points: List[BaseHandler[Update, CCT]],
-        states: Dict[object, List[BaseHandler[Update, CCT]]],
-        fallbacks: List[BaseHandler[Update, CCT]],
+        self: "ConversationHandler[CCT]",
+        entry_points: List[BaseHandler[Update, CCT, object]],
+        states: Dict[object, List[BaseHandler[Update, CCT, object]]],
+        fallbacks: List[BaseHandler[Update, CCT, object]],
         allow_reentry: bool = False,
         per_chat: bool = True,
         per_user: bool = True,
@@ -324,9 +324,9 @@ class ConversationHandler(BaseHandler[Update, CCT]):
         # Store the actual setting in a protected variable instead
         self._block: DVType[bool] = block
 
-        self._entry_points: List[BaseHandler[Update, CCT]] = entry_points
-        self._states: Dict[object, List[BaseHandler[Update, CCT]]] = states
-        self._fallbacks: List[BaseHandler[Update, CCT]] = fallbacks
+        self._entry_points: List[BaseHandler[Update, CCT, object]] = entry_points
+        self._states: Dict[object, List[BaseHandler[Update, CCT, object]]] = states
+        self._fallbacks: List[BaseHandler[Update, CCT, object]] = fallbacks
 
         self._allow_reentry: bool = allow_reentry
         self._per_user: bool = per_user
@@ -359,7 +359,7 @@ class ConversationHandler(BaseHandler[Update, CCT]):
                 stacklevel=2,
             )
 
-        all_handlers: List[BaseHandler[Update, CCT]] = []
+        all_handlers: List[BaseHandler[Update, CCT, object]] = []
         all_handlers.extend(entry_points)
         all_handlers.extend(fallbacks)
 
@@ -466,7 +466,7 @@ class ConversationHandler(BaseHandler[Update, CCT]):
         )
 
     @property
-    def entry_points(self) -> List[BaseHandler[Update, CCT]]:
+    def entry_points(self) -> List[BaseHandler[Update, CCT, object]]:
         """List[:class:`telegram.ext.BaseHandler`]: A list of :obj:`BaseHandler` objects that can
         trigger the start of the conversation.
         """
@@ -479,7 +479,7 @@ class ConversationHandler(BaseHandler[Update, CCT]):
         )
 
     @property
-    def states(self) -> Dict[object, List[BaseHandler[Update, CCT]]]:
+    def states(self) -> Dict[object, List[BaseHandler[Update, CCT, object]]]:
         """Dict[:obj:`object`, List[:class:`telegram.ext.BaseHandler`]]: A :obj:`dict` that
         defines the different states of conversation a user can be in and one or more
         associated :obj:`BaseHandler` objects that should be used in that state.
@@ -491,7 +491,7 @@ class ConversationHandler(BaseHandler[Update, CCT]):
         raise AttributeError("You can not assign a new value to states after initialization.")
 
     @property
-    def fallbacks(self) -> List[BaseHandler[Update, CCT]]:
+    def fallbacks(self) -> List[BaseHandler[Update, CCT, object]]:
         """List[:class:`telegram.ext.BaseHandler`]: A list of handlers that might be used if
         the user is in a conversation, but every handler for their current state returned
         :obj:`False` on :meth:`check_update`.
diff --git a/telegram/ext/_handlers/inlinequeryhandler.py b/telegram/ext/_handlers/inlinequeryhandler.py
index 21a5925cb..9d2cbb710 100644
--- a/telegram/ext/_handlers/inlinequeryhandler.py
+++ b/telegram/ext/_handlers/inlinequeryhandler.py
@@ -32,7 +32,7 @@ if TYPE_CHECKING:
 RT = TypeVar("RT")
 
 
-class InlineQueryHandler(BaseHandler[Update, CCT]):
+class InlineQueryHandler(BaseHandler[Update, CCT, RT]):
     """
     BaseHandler class to handle Telegram updates that contain a
     :attr:`telegram.Update.inline_query`.
@@ -87,7 +87,7 @@ class InlineQueryHandler(BaseHandler[Update, CCT]):
     __slots__ = ("chat_types", "pattern")
 
     def __init__(
-        self,
+        self: "InlineQueryHandler[CCT, RT]",
         callback: HandlerCallback[Update, CCT, RT],
         pattern: Optional[Union[str, Pattern[str]]] = None,
         block: DVType[bool] = DEFAULT_TRUE,
diff --git a/telegram/ext/_handlers/messagehandler.py b/telegram/ext/_handlers/messagehandler.py
index 0cd42884b..43d8c8d81 100644
--- a/telegram/ext/_handlers/messagehandler.py
+++ b/telegram/ext/_handlers/messagehandler.py
@@ -32,7 +32,7 @@ if TYPE_CHECKING:
 RT = TypeVar("RT")
 
 
-class MessageHandler(BaseHandler[Update, CCT]):
+class MessageHandler(BaseHandler[Update, CCT, RT]):
     """Handler class to handle Telegram messages. They might contain text, media or status
     updates.
 
@@ -75,7 +75,7 @@ class MessageHandler(BaseHandler[Update, CCT]):
     __slots__ = ("filters",)
 
     def __init__(
-        self,
+        self: "MessageHandler[CCT, RT]",
         filters: Optional[filters_module.BaseFilter],
         callback: HandlerCallback[Update, CCT, RT],
         block: DVType[bool] = DEFAULT_TRUE,
diff --git a/telegram/ext/_handlers/messagereactionhandler.py b/telegram/ext/_handlers/messagereactionhandler.py
index 4b52a17a8..34a5292be 100644
--- a/telegram/ext/_handlers/messagereactionhandler.py
+++ b/telegram/ext/_handlers/messagereactionhandler.py
@@ -28,7 +28,7 @@ from telegram.ext._utils._update_parsing import parse_chat_id, parse_username
 from telegram.ext._utils.types import CCT, HandlerCallback
 
 
-class MessageReactionHandler(BaseHandler[Update, CCT]):
+class MessageReactionHandler(BaseHandler[Update, CCT, RT]):
     """Handler class to handle Telegram updates that contain a message reaction.
 
     Note:
@@ -110,7 +110,7 @@ class MessageReactionHandler(BaseHandler[Update, CCT]):
     and :attr:`telegram.Update.message_reaction_count`."""
 
     def __init__(
-        self,
+        self: "MessageReactionHandler[CCT, RT]",
         callback: HandlerCallback[Update, CCT, RT],
         chat_id: Optional[SCT[int]] = None,
         chat_username: Optional[SCT[str]] = None,
diff --git a/telegram/ext/_handlers/pollanswerhandler.py b/telegram/ext/_handlers/pollanswerhandler.py
index 91e8df82b..5e0bb34db 100644
--- a/telegram/ext/_handlers/pollanswerhandler.py
+++ b/telegram/ext/_handlers/pollanswerhandler.py
@@ -21,10 +21,10 @@
 
 from telegram import Update
 from telegram.ext._handlers.basehandler import BaseHandler
-from telegram.ext._utils.types import CCT
+from telegram.ext._utils.types import CCT, RT
 
 
-class PollAnswerHandler(BaseHandler[Update, CCT]):
+class PollAnswerHandler(BaseHandler[Update, CCT, RT]):
     """Handler class to handle Telegram updates that contain a
     :attr:`poll answer <telegram.Update.poll_answer>`.
 
diff --git a/telegram/ext/_handlers/pollhandler.py b/telegram/ext/_handlers/pollhandler.py
index fb183c538..6bb41c323 100644
--- a/telegram/ext/_handlers/pollhandler.py
+++ b/telegram/ext/_handlers/pollhandler.py
@@ -21,10 +21,10 @@
 
 from telegram import Update
 from telegram.ext._handlers.basehandler import BaseHandler
-from telegram.ext._utils.types import CCT
+from telegram.ext._utils.types import CCT, RT
 
 
-class PollHandler(BaseHandler[Update, CCT]):
+class PollHandler(BaseHandler[Update, CCT, RT]):
     """Handler class to handle Telegram updates that contain a
     :attr:`poll <telegram.Update.poll>`.
 
diff --git a/telegram/ext/_handlers/precheckoutqueryhandler.py b/telegram/ext/_handlers/precheckoutqueryhandler.py
index 3c6f3f186..de035364e 100644
--- a/telegram/ext/_handlers/precheckoutqueryhandler.py
+++ b/telegram/ext/_handlers/precheckoutqueryhandler.py
@@ -31,7 +31,7 @@ from telegram.ext._utils.types import CCT, HandlerCallback
 RT = TypeVar("RT")
 
 
-class PreCheckoutQueryHandler(BaseHandler[Update, CCT]):
+class PreCheckoutQueryHandler(BaseHandler[Update, CCT, RT]):
     """Handler class to handle Telegram :attr:`telegram.Update.pre_checkout_query`.
 
     Warning:
@@ -73,7 +73,7 @@ class PreCheckoutQueryHandler(BaseHandler[Update, CCT]):
     __slots__ = ("pattern",)
 
     def __init__(
-        self,
+        self: "PreCheckoutQueryHandler[CCT, RT]",
         callback: HandlerCallback[Update, CCT, RT],
         block: DVType[bool] = DEFAULT_TRUE,
         pattern: Optional[Union[str, Pattern[str]]] = None,
diff --git a/telegram/ext/_handlers/prefixhandler.py b/telegram/ext/_handlers/prefixhandler.py
index 3b10a0a1c..bda265e10 100644
--- a/telegram/ext/_handlers/prefixhandler.py
+++ b/telegram/ext/_handlers/prefixhandler.py
@@ -33,7 +33,7 @@ if TYPE_CHECKING:
 RT = TypeVar("RT")
 
 
-class PrefixHandler(BaseHandler[Update, CCT]):
+class PrefixHandler(BaseHandler[Update, CCT, RT]):
     """Handler class to handle custom prefix commands.
 
     This is an intermediate handler between :class:`MessageHandler` and :class:`CommandHandler`.
@@ -123,7 +123,7 @@ class PrefixHandler(BaseHandler[Update, CCT]):
     __slots__ = ("commands", "filters")
 
     def __init__(
-        self,
+        self: "PrefixHandler[CCT, RT]",
         prefix: SCT[str],
         command: SCT[str],
         callback: HandlerCallback[Update, CCT, RT],
diff --git a/telegram/ext/_handlers/shippingqueryhandler.py b/telegram/ext/_handlers/shippingqueryhandler.py
index f0234c2a9..c18651309 100644
--- a/telegram/ext/_handlers/shippingqueryhandler.py
+++ b/telegram/ext/_handlers/shippingqueryhandler.py
@@ -21,10 +21,10 @@
 
 from telegram import Update
 from telegram.ext._handlers.basehandler import BaseHandler
-from telegram.ext._utils.types import CCT
+from telegram.ext._utils.types import CCT, RT
 
 
-class ShippingQueryHandler(BaseHandler[Update, CCT]):
+class ShippingQueryHandler(BaseHandler[Update, CCT, RT]):
     """Handler class to handle Telegram :attr:`telegram.Update.shipping_query`.
 
     Warning:
diff --git a/telegram/ext/_handlers/stringcommandhandler.py b/telegram/ext/_handlers/stringcommandhandler.py
index d5c29bf66..ff655d9d6 100644
--- a/telegram/ext/_handlers/stringcommandhandler.py
+++ b/telegram/ext/_handlers/stringcommandhandler.py
@@ -29,7 +29,7 @@ if TYPE_CHECKING:
     from telegram.ext import Application
 
 
-class StringCommandHandler(BaseHandler[str, CCT]):
+class StringCommandHandler(BaseHandler[str, CCT, RT]):
     """Handler class to handle string commands. Commands are string updates that start with
     ``/``. The handler will add a :obj:`list` to the
     :class:`CallbackContext` named :attr:`CallbackContext.args`. It will contain a list of strings,
@@ -71,7 +71,7 @@ class StringCommandHandler(BaseHandler[str, CCT]):
     __slots__ = ("command",)
 
     def __init__(
-        self,
+        self: "StringCommandHandler[CCT, RT]",
         command: str,
         callback: HandlerCallback[str, CCT, RT],
         block: DVType[bool] = DEFAULT_TRUE,
diff --git a/telegram/ext/_handlers/stringregexhandler.py b/telegram/ext/_handlers/stringregexhandler.py
index c2e22c106..bd9746949 100644
--- a/telegram/ext/_handlers/stringregexhandler.py
+++ b/telegram/ext/_handlers/stringregexhandler.py
@@ -32,7 +32,7 @@ if TYPE_CHECKING:
 RT = TypeVar("RT")
 
 
-class StringRegexHandler(BaseHandler[str, CCT]):
+class StringRegexHandler(BaseHandler[str, CCT, RT]):
     """Handler class to handle string updates based on a regex which checks the update content.
 
     Read the documentation of the :mod:`re` module for more information. The :func:`re.match`
@@ -74,7 +74,7 @@ class StringRegexHandler(BaseHandler[str, CCT]):
     __slots__ = ("pattern",)
 
     def __init__(
-        self,
+        self: "StringRegexHandler[CCT, RT]",
         pattern: Union[str, Pattern[str]],
         callback: HandlerCallback[str, CCT, RT],
         block: DVType[bool] = DEFAULT_TRUE,
diff --git a/telegram/ext/_handlers/typehandler.py b/telegram/ext/_handlers/typehandler.py
index 151a7fbf1..48a4530bc 100644
--- a/telegram/ext/_handlers/typehandler.py
+++ b/telegram/ext/_handlers/typehandler.py
@@ -29,7 +29,7 @@ RT = TypeVar("RT")
 UT = TypeVar("UT")
 
 
-class TypeHandler(BaseHandler[UT, CCT]):
+class TypeHandler(BaseHandler[UT, CCT, RT]):
     """Handler class to handle updates of custom types.
 
     Warning:
@@ -70,7 +70,7 @@ class TypeHandler(BaseHandler[UT, CCT]):
     __slots__ = ("strict", "type")
 
     def __init__(
-        self,
+        self: "TypeHandler[UT, CCT, RT]",
         type: Type[UT],  # pylint: disable=redefined-builtin
         callback: HandlerCallback[UT, CCT, RT],
         strict: bool = False,