python-telegram-bot/docs/source/inclusions/application_run_tip.rst

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.. tip::
* When combining ``python-telegram-bot`` with other :mod:`asyncio` based frameworks, using this
method is likely not the best choice, as it blocks the event loop until it receives a stop
signal as described above.
Instead, you can manually call the methods listed below to start and shut down the application
and the :attr:`~telegram.ext.Application.updater`.
Keeping the event loop running and listening for a stop signal is then up to you.
* To gracefully stop the execution of this method from within a handler, job or error callback,
use :meth:`~telegram.ext.Application.stop_running`.